I'M so glad this thread did SO well!
Happy you enjoyed it!
For all those who did let me relate my own experience, because I know you care. ;*)
Fasting is hard werk. Not many people can really do it, or do it consistently, even David Sinclair admitted he couldn't. However, Intermittent Fasting can accomplish the same thing; resetting your body to a much finer tuning, add years to your biological life, and it's a whole lot easier to do.
It's basically as easy as skipping breakfast, as some people already do, or skipping dinner as others do. The idea is to get 12 or 14 or 16 hours without eating, and 8 hours to eat.
Most people start slow, and here's how they do it. They sleep for 8 hours, skip breakfast; have coffee or green tea (or matcha) instead. And lots of water. When they get hungry, they know that the pang will go away in 15 or 20 mins for most, but suffering is not necessary; have some 80 percent or so dark chocolate with your coffee instead.... that's what sold me!
So now at noon you have 8 hours sleep and say 4 hours fasting, so that's a good start. Do it a couple of times a week, then go for 14 and then 16 hours, which gets easier as you go along. Then go for several days a week, then maybe every day.
At that point your body is in peak operation mode. You should walk a lot, don't sit as much, and drink lots of water. Avoid the biggest killer in your diet, SUGAR, cut back on salt and no processed meats. Use monkfruit as a sugar substitute with all that coffee.
I lost over 50 lbs in about 6 mos, went off of it mostly for nearly a year as I traveled, and never regained the weight. I'm back on it now.
The article and the videos are by people who really know the science, but I thought to give you a practical comment on actually doing it.
They also talk about common supplements and not so common ones. Omega 3, Magnesium, Vit D + K2.
Also, some not so common supplements that Sinclair and Huberman discuss in the video.
Cheers!