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#2 | Posted by HeliumRat at 2024-02-02 03:56 PM
Finally, and most importantly, the authors propose a specific location in the genome where they will insert these furin cleavage sites: the S1/S2 boundary, a narrow window in a 3,600 nucleotide gene, and SARS-CoV-2 has its furin cleavage site at exactly the location proposed in these grants."
Damning.
Not "damning" - debunked as "evidence" of "man-made" long time ago - many sources on the Web:
pubs.asahq.org - COVID Gets Complicated
Variant soup | Quasispecies | S-protein/mRNA nuclear translocation | Amyloidogenesis of spike protein | In the Know | Volume 87, Issue 1 - January 2023
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... "This finding may explain, at least in part, the extraordinary rapid worldwide turnover of variants of concern that use the plasma membrane fusion pathway to enter into target cells over the original pandemic strain."
S-protein/mRNA nuclear translocation
A recent preprint from researchers at the National Institute of Allergy and Infectious Diseases described a feature of SARS-CoV-2 unique among betacoronaviruses: the spike protein of SARS-CoV-2, along with its corresponding mRNA, can translocate to the cellular nucleus in infected airway epithelial cells (bioRxiv 2022:2022.09.27.509633). In SARS-CoV-2, the peptide sequence "P-R-R-A-R-S-V" constitutes a nuclear localization signal, a sequence that includes the so-called "furin cleavage site." This polybasic cleavage site was initially thought to be unique to SARS-CoV-2, and possibly evidence of human genomic engineering. It has since been identified in other coronaviruses (ASA Monitor 2021:85:1-6). It is possible that the translocation of the spike protein contributes to the uniquely rapid evolution and development of immune evasion by SARS-CoV-2. ...
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www.nature.com - The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets - Nature, 2021-04-27
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SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2' cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (PRRAR) at the S1/S2 cleavage site that can be cleaved by furin. ...
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Pick better sources than the ones that keep rehashing debunked information from years ago.
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