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Thursday, January 29, 2015

straZeneca said on Thursday it had struck four research agreements in the hot area of genome editing as it bets on a new "genetic scissors" technology to deliver better and more precise drugs for a range of diseases.

The academic and commercial tie-ups will allow British-based AstraZeneca to use so-called CRISPR technology across its entire drug discovery platform in areas such as oncology, cardiovascular, respiratory and immune system medicine.

CRISPR, which stands for clustered regularly interspaced short palindromic repeats, allows scientists to edit the genes of selected cells accurately and efficiently. It has created excitement since emerging two years ago and is already being tipped for a Nobel Prize. read more


Carl Krawitt has watched his son, Rhett, now 6, fight leukemia for the past 4 1/2 years. For more than three of those years, Rhett has undergone round after round of chemotherapy. Last year he finished chemotherapy, and doctors say he is in remission. Now, there's a new threat, one that the family should not have to worry about: measles. Rhett cannot be vaccinated, because his immune system is still rebuilding. It may be months more before his body is healthy enough to get all his immunizations. Until then, he depends on everyone around him for protection -- what's known as herd immunity. But Rhett lives in Marin County, Calif., a county with the dubious honor of having the highest rate of "personal belief exemptions" in the Bay Area and among the highest in the state. This school year, 6.45 percent of children in Marin have a personal belief exemption, which allows parents to lawfully send their children to school unvaccinated against communicable diseases like measles, polio, whooping cough and more. read more


Tuesday, January 27, 2015

The Supreme Court cast doubt Monday on the future of old union contracts that had promised lifetime health benefits for retired workers and their families. In a case seen as a victory for corporate America, the justices ruled these promises should not be treated as "vested rights" unless they are spelled out in the contract. "When a contract is silent as to the duration of retiree benefits, a court may not infer that the parties intended those benefits to vest for life," wrote Justice Clarence Thomas. read more


Monday, January 26, 2015

Veronica Partridge is causing quite a stir online due to her blog post about why she no longer wears leggings. The Christian blogger states that when women wear leggings, "it creates a stronger attraction for a man to look at a woman's body and may cause them to think lustful thoughts."

read more


Sunday, January 18, 2015

In a new study, scientists at Arizona State University (ASU), Tempe, quantified the different metals in sewage sludge and estimated what it all might be worth. They took sludge samples gathered from around the country and measured the metal content using a mass spectrometer that can discern different elements as they are ionized in a superhot plasma. The upshot: There's as much as $13 million worth of metals in the sludge produced every year by a million-person city, including $2.6 million in gold and silver read more


Comments

WD - Here is the answer: www.drudge.com

But nobody knew that this would come from the research. Sometimes you just have to look for SOMETHING to find something new. How else do you find something that only bacteria and God know exist?

If you're working so hard, what is the value of what you are working on? Will it sell in the market? If not, why are you doing it?
You don't realize that unless you're working on something that will be actually profitable to the state, then you're making my point for me: lots of people, spending lots of time, doing things that aren't worth doing. No business or household can run that way. So if you're doing work of great value for pay that you don't believe is sufficient, why not quit and work for HP instead? Or Google? Isn't that the smart thing to do?

#16 | POSTED BY WHITEDEVIL AT 2015-01-29 02:55 AM | FLAG:

Sure. Here is an example of some work done a few years ago. Would you consider it worthy?

Nucleic Acids Res. 2002 Jan 15;30(2):482-96.
A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis.
Makarova KS1, Aravind L, Grishin NV, Rogozin IB, Koonin EV.
Author information
Abstract
During a systematic analysis of conserved gene context in prokaryotic genomes, a previously undetected, complex, partially conserved neighborhood consisting of more than 20 genes was discovered in most Archaea (with the exception of Thermoplasma acidophilum and Halobacterium NRC-1) and some bacteria, including the hyperthermophiles Thermotoga maritima and Aquifex aeolicus. The gene composition and gene order in this neighborhood vary greatly between species, but all versions have a stable, conserved core that consists of five genes. One of the core genes encodes a predicted DNA helicase, often fused to a predicted HD-superfamily hydrolase, and another encodes a RecB family exonuclease; three core genes remain uncharacterized, but one of these might encode a nuclease of a new family. Two more genes that belong to this neighborhood and are present in most of the genomes in which the neighborhood was detected encode, respectively, a predicted HD-superfamily hydrolase (possibly a nuclease) of a distinct family and a predicted, novel DNA polymerase. Another characteristic feature of this neighborhood is the expansion of a superfamily of paralogous, uncharacterized proteins, which are encoded by at least 20-30% of the genes in the neighborhood. The functional features of the proteins encoded in this neighborhood suggest that they comprise a previously undetected DNA repair system, which, to our knowledge, is the first repair system largely specific for thermophiles to be identified. This hypothetical repair system might be functionally analogous to the bacterial-eukaryotic system of translesion, mutagenic repair whose central components are DNA polymerases of the UmuC-DinB-Rad30-Rev1 superfamily, which typically are missing in thermophiles.
PMID: 11788711 [PubMed - indexed for MEDLINE] PMCID: PMC99818 Free PMC Article

Another: www.rsc.org

The team monitored download data in April during the working week and over two separate weekends, dividing each day into 144 slots of 10 minutes. The researchers focused on the three biggest downloaders: the US (29.6% of total), Germany (15%), and China (9.6%). The UK came in at fourth place with 3.9% of total downloads.

scientists working
Chinese scientists are more likely to be downloading papers at weekends than their counterparts in the US and Germany. © Elsevier
Unsurprisingly, downloads in the three countries slowed down during the night and on weekends, but never ceased. However, scientists in the US were most likely to be working through the night, with post-midnight to sunrise downloads remaining between 100 and 300 downloads for each 10-minute time slot, compared with the weekday late afternoon highs of around 700 downloads. Downloads in Germany and China generally tapered off sharply after midnight to below 50 downloads every 10 minutes until sunrise.

On weekends, night time downloads in all three nations were nearly identical to night time downloads on weekdays. However, weekend downloads during the day in all three nations were down from weekday levels, but not as sharply in China as in the US and Germany.

Lead author Xianwen Wang says the large number of downloads during the night and on weekends was ‘quite beyond my expectation'. Although his team only relied on Springer download data for the study, he thinks data from other global science publishers would show a similar trend.

You don't have to believe me on working hours either. It's been well documented. Try this one: www.nature.com

"In a lab where the boss calls you at 6 a.m., schedules Friday evening lab meetings that can stretch past 10 p.m., and routinely expects you to work over Christmas, sticking it out until midnight on a holiday weekend is nothing unusual."

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