Drudge Retort: The Other Side of the News
Thursday, August 07, 2014

Researchers have discovered a new drug compound that reverses the brain deficits of Alzheimer's disease in an animal model. The compound, TC-2153, inhibits the negative effects of a protein called STtriatal-Enriched tyrosine Phosphatase (STEP), which is key to regulating learning and memory. "The small molecule inhibitor is the result of a five-year collaborative effort to search for STEP inhibitors," said Lombroso. "A single dose of the drug results in improved cognitive function in mice. Animals treated with TC compound were indistinguishable from a control group in several cognitive tasks."

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HeliumRat

 

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Admin's note: Participants in this discussion must follow the site's moderation policy. Profanity will be filtered. Abusive conduct is not allowed.

Cool! It might work on those suffering from the brain defect causing liberalism too.

#1 | Posted by Huguenot at 2014-08-06 04:46 PM | Reply | Flag:

Unfortunately the researchers found that the drug compound "had absolutely no effect on folks suffering from Obama deraignment syndrome"

The team is currently testing the TC compound in other mammals with cognitive defects, including conservatives, tea partiers, gun nuts, NRA members, vigilantes, succession advocates, sovereign citizens and rats and non-human primates,

#2 | Posted by SammyAZ_RI at 2014-08-06 05:22 PM | Reply | Flag: | Funny: 1

As an anticataleptic this would make it nearly impossible to distinguish between animals with end-stage mad cow. Clever.

#3 | Posted by redlightrobot at 2014-08-06 08:33 PM | Reply | Flag:

#3 Mad cow is a prion disease. Alzheimers is caused by a protein plaque.

There is a difference. So it won't work on mad cows.

Where do you get this stuff?

#4 | Posted by HeliumRat at 2014-08-06 09:26 PM | Reply | Flag:

Another interesting (and related only by subject) was this in the journal Neurology:

Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease.

www.neurology.org

And while possible prevention is a nice way to go, this article on reversing and allowing the connections for memory to be made could be so significant for so many. Including someone I know that was just diagnosed. I have my fingers crossed.

#5 | Posted by YAV at 2014-08-06 09:40 PM | Reply | Flag:

You know, I realize that taking baby steps and having plans to test this on every other quadraped and biped on the planet before testing it on humans is the absolute safest way to go, but don't you think if they asked for volunteers, they would have thousands of people recently diagnosed with Alheimers lining up to be test subjects?

#6 | Posted by MUSTANG at 2014-08-07 11:25 AM | Reply | Flag:

And, they wouldn't remember they volunteered. Win-win.

#7 | Posted by Harry_Powell at 2014-08-07 12:14 PM | Reply | Flag: | Funny: 1

#7 Dude, that's COLD...and funny.

#8 | Posted by MUSTANG at 2014-08-07 12:24 PM | Reply | Flag:

they would have thousands of people recently diagnosed with Alheimers lining up to be test subjects?

#6 | POSTED BY MUSTANG AT 2014-08-07 11:25 AM | REPLY | FLAG

That is no different than any life saving drug. You still have to follow proper protocols.

#9 | Posted by 726 at 2014-08-07 03:38 PM | Reply | Flag:

That is no different than any life saving drug. You still have to follow proper protocols.

#9 | Posted by 726

In a situation where the disease is as life altering as Alzheimer's, there's no reason why the protocols can't be altered and or accelerated. In this case, it's hard to imagine the treatment causing a worse outcome than the disease.

#10 | Posted by Whatsleft at 2014-08-07 04:32 PM | Reply | Flag: | Newsworthy 1

#1 | Posted by Huguenot

In Huguenot world.. If a liberal has an idea it's bad. If a conservative has an idea it's good. If a conservative has a good idea, and then a liberal agrees with it, it must not have been a good idea after all.

Does that sum it up?

#11 | Posted by Whatsleft at 2014-08-07 04:37 PM | Reply | Flag:

Does that sum it up?

Yes probably, except Republicans have ideas so rarely, it's hard to draw a firm conclusion.
In the interest of clarity, let's use the term 'Republican pavlovian response" instead of "idea".

#12 | Posted by northguy3 at 2014-08-07 07:41 PM | Reply | Flag:

Dementia and cancer are two of the most costly debilitating diseases in the world, and both could have been cured had not the USA-Israeli neocons wanted to keep the world at war blowing up buildings and killing civilians for decades now just to satisfy their own greedy banker interests.

#13 | Posted by Robson at 2014-08-07 07:48 PM | Reply | Flag:

Are they ready for human trials yet?

#14 | Posted by Tor at 2014-08-08 02:30 AM | Reply | Flag:

#3 Mad cow is a prion disease. Alzheimers is caused by a protein plaque.
There is a difference. So it won't work on mad cows.
Where do you get this stuff?
#4 | Posted by HeliumRat at 2014-08-06 09:26 PM

I'm uncertain what muscular control dissimilarity between the "two" ailments would prove other than they are . Both involve malformed prions changing existing brain into limited organ structure which inhibits short-term memory, long-term memory, disables motor control causing myoclonus, etc - so the resulting tremors are brain damage, this specific drug happens to mask that symptom, apparently along with the short-term memory loss which the article is touting - but it does not "fix" the organ whatsoever. What I'm presuming is that this will become yet another "factory farming preventative tool" implemented along with the arrays of hormones and anti-virus we currently experience in food. This will prevent the "visual" cues of a diseased animal entering into the "humans food chain", saving countless dollars, infecting countless "food" consumers. This is money injected directly into insurance mechanism, which then trickles it through medical institutions using specific pharmaceutical answers such as this current "reverses brain deficits" drug.

There are currently estimated 5.3 million Americans with Alzheimer's disease. 5.1 are over 65 and about 13% are conclusively misdiagnosed CJG . There are two avenues of research - this specific one is to ameliorate some conditions of the disease, but not to cure. This will be exploited, imo.

#15 | Posted by redlightrobot at 2014-08-08 01:34 PM | Reply | Flag:

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