Drudge Retort: Red Meat for Yellow Dogs
Thursday, February 25, 2010

An extremely small RNA molecule created by a University of Colorado at Boulder team can catalyze a key reaction needed to synthesize proteins, the building blocks of life. The findings could be a substantial step toward understanding "the very origin of Earthly life," the lead researcher contends. Yarus' team focused on a ribozyme -- a form of RNA that can catalyze chemical reactions -- with only five nucleotides.

"In this paper the Yarus group has made the amazing discovery that even an extremely tiny RNA can by itself catalyze a key reaction that would be needed to synthesize proteins," Blumenthal said. "Nobody expected an RNA molecule this small and simple to be able to do such a complicated thing as that."

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The Tea Party is rushing to sign up the intelegent molecules as potential Congressional candidate in the 2010 election.

"They are probably a lot smarter than the bunch of yahoos we got now." said de-facto Tea Party leader Vernon Hootch of Spring, Texas.

The Tea Party is rushing to sign up the intelegent molecules as potential Congressional candidate in the 2010 election.

I wouldn't go so far as to call a ribozyme "intelligent," but you've got a point... those 5 nucleotides are capable of accomplishing more than any 5 teabaggers.

God I hate popular science writing.

They never actually say what the damned RNA did (which is sort of important...).

Cool paper though.

They never actually say what the damned RNA did (which is sort of important...).

Well, from reading the thing on science daily I thought it was catalyzing peptide bond formation. It looks like it catalyzes formation of the bond between phenylalanine and the appropriate tRNA. Not quite sure what they mean by "The initial 2(') Phe-RNA product can be elaborated into multiple peptidyl-RNAs." The PNAS site is having trouble, so maybe try for the article in an hour or so. Here's the abstract from pubmed.

God I hate popular science writing.

And sciencedaily is one of the better ones. Well, it's hit or miss but compared to what I read in my local paper it's pretty good.

So I guess it's my bad on the headline. Oh well.

I wouldn't go so far as to call a ribozyme "intelligent,"

I guess a ribozyme would have an "r" after it's name.
Little r, to distinguish.

Well, from reading the thing on science daily I thought it was catalyzing peptide bond formation.

That was exactly what I was thinking and I'm sure that's what they wanted me to think.

It looks like it catalyzes formation of the bond between phenylalanine and the appropriate tRNA.

Yeah I pulled the PNAS paper from the link on the bottom of the page.

And sciencedaily is one of the better ones. Well, it's hit or miss but compared to what I read in my local paper it's pretty good.

Which is why it's disconcerting.

It's clear they were too busy pushing the RNA world significance to
accurately describe the science.

The finding adds weight to the "RNA World" hypothesis, which proposes that life on Earth evolved from early forms of RNA. "Mike Yarus has been one of the strongest proponents of this idea, and his lab has provided some of the strongest evidence for it over the past two decades," Blumenthal said.

Yarus noted that the RNA World hypothesis was complicated by the fact that RNA molecules are hard to make. "This work shows that RNA enzymes could have been far smaller, and therefore far easier to make under primitive conditions, than anyone has expected."

If very simple RNA molecules such as the product of the Yarus lab could have accelerated chemical reactions in Earth's primordial stew, the chances are much greater that RNA could direct and accelerate biochemical reactions under primitive conditions.

"If there exists that kind of mini-catalyst, a 'sister' to the one we describe, the world of the replicators would also jump a long step closer and we could really feel we were closing in on the first things on Earth that could undergo Darwinian evolution," Yarus said.

"In other words, we may have taken a substantial step toward the very origin of Earthly life," he said. "However, keep well in mind that the tiny replicator has not been found, and that its existence will be decided by experiments not yet done, perhaps not yet imagined."

Simple RNA molecules can catalyze protein synthesis. Therefore, "we may have taken a substantial step toward the very origin of Earthly life".

"The tiny replicator has not yet been found".

Really? The missing 'tiny replicator' is insignificant in light of a gaping hole in the 'RNA World' theory and the 'breakthrough' ignores the underlying problem as well. The theory is just one of many "naturalistic mechanisms of life" fallacies.

What becomes obvious is that evolutionists are really exercising their imaginations rather than engaging in real research as they come up with their origin-of-life theories. In fact, a million-dollar 'The Origin of Life Prize' is being offered "for proposing a highly plausible mechanism for the spontaneous rise of genetic instructions in nature sufficient to give rise to life."

In order for evolution to have something to tinker with, the first life-form would have had to have been astoundingly complex, not super simple.

An additional problem that is faced is the need for energy for the interactions to take place, a so-called "driver reaction." The formation of energy (in the form of ATP) in the cell is no simple process. It requires many complex molecules all interacting with one another in a stepwise fashion to produce the energy needed for life. "The chances that blind, undirected, inanimate chemistry would go out of its way in multiple steps and use of reagents in just the right sequence to form RNA is highly unlikely," argues Robert Shapiro. Instead, he advocates the metabolism-first argument: that early self-sustaining autocatalytic chemosynthetic systems associated with amino acids predated RNA.

What becomes obvious is that evolutionists are really exercising their imaginations rather than engaging in real research as they come up with their origin-of-life theories. In fact, a million-dollar 'The Origin of Life Prize' is being offered "for proposing a highly plausible mechanism for the spontaneous rise of genetic instructions in nature sufficient to give rise to life."
In order for evolution to have something to tinker with, the first life-form would have had to have been astoundingly complex, not super simple.
An additional problem that is faced is the need for energy for the interactions to take place, a so-called "driver reaction." The formation of energy (in the form of ATP) in the cell is no simple process. It requires many complex molecules all interacting with one another in a stepwise fashion to produce the energy needed for life. "The chances that blind, undirected, inanimate chemistry would go out of its way in multiple steps and use of reagents in just the right sequence to form RNA is highly unlikely," argues Robert Shapiro. Instead, he advocates the metabolism-first argument: that early self-sustaining autocatalytic chemosynthetic systems associated with amino acids predated RNA.
#9 | Posted by L_RContrarian at 2010-02-25 11:16 PM

Does he mean vast community organisms or extremely specialized complex individuals? This seems counter-intuitive, Contrarian.:]

"The tiny replicator has not yet been found".

Yet. It doesn't exist anymore... only its descendents do. Within a single human lifetime, science has demystified processes that took hundreds of millions of years on the ancient earth. With each passing day, though, more is known about the characteristics those "tiny replicators" would have possessed. More is known about the mechanisms by which all of life's essential chemical reactions could have taken place in the prebiotic earth. Every couple of months, someone publishes an account of yet another small but profound step toward the description of the origin of life on earth.

You're a fucking idiot if you think that life must be re-created in a test tube to "prove" abiogenesis superior to creationism. Creationism was left in the dust the day that scientists began posing testable hypotheses based on mechanisms consistent with observations. Please, LR, continue to babble on about purported "flaws" in a subject matter you know jack shit about. It's rather entertaining to see a fool parade his ignorance around as if it is some sort of redeeming quality.

An additional problem that is faced is the need for energy for the interactions to take place, a so-called "driver reaction." The formation of energy (in the form of ATP) in the cell is no simple process.

Let me fix that for you: The efficient formation of ATP from glucose, amino acids, and lipids is no simple process in living organisms. The first syntheses of energy carriers on Earth did not need to be terribly efficient or even remotely resemble what occurs in extant life forms.

There are other energy carriers and redox-active molecules that would have been readily available on the early earth. Not every reaction in an organism requires the input of energy, but prebiotic "enzymes" could couple the release of the energy present in these carrier molecules to unfavorable chemical reactions.

Pyrophosphate can form when you dry a puddle of water containing dissolved phosphate. Hydrolysis of pyrophosphate releases as much energy as the hydrolysis of ATP to ADP. Things like rhodopsins can store light energy in a chemical bond. Flavins, quinones, metal complexes... there is a galaxy of fairly simple organic and inorganic molecules that can participate in redox chemistry. Moreover, these sorts of energy carriers could be "charged up" by environmental processes.

Cool, cool stuff, Zombie.

This guy is a client of ours here in Naples, and we were fascinated listening to him in our offices the other day go on about his physics theories.

www.stenosphere.com

www.youtube.com

Scientific experimentation apparently should be assumed true in the very premise/assumptions made for futhering the research, especially when the scientists are close-minded evolutionist that have already pre-ordained the results; therefore, "we may have taken a substantial step toward the very origin of Earthly life".

#10 redlight
Certainly you've dug in enough to visit his Wiki and background to realize that Robert Shapiro is a renowned, leading expert. Perhaps you should visit his research and pursue it if you have an intelligent question.

In order for evolution to have something to tinker with, the first life-form would have had to have been astoundingly complex, not super simple.

Absolutely untrue.

Experiments have been done showing that competition between self-replicating RNA molecules results in the evolution of the RNA molecules to a more efficient sequence and form.

Evolution has no complexity requirement.

Scientific experimentation apparently should be assumed true in the very premise/assumptions made for futhering the research, especially when the scientists are close-minded evolutionist that have already pre-ordained the results; therefore, "we may have taken a substantial step toward the very origin of Earthly life".

What?

to realize that Robert Shapiro is a renowned, leading expert

Code for 'I agree with him.'

And the people who conducted the experiment in the link, they're not experts? Or is it your expert opinion deciding who is or isn't an expert?

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